Is cranial computerized tomography useful in the diagnosis of multiple system atrophy?
Identifieur interne : 005B60 ( Main/Exploration ); précédent : 005B59; suivant : 005B61Is cranial computerized tomography useful in the diagnosis of multiple system atrophy?
Auteurs : Wenning [Royaume-Uni] ; R. J Ger [Royaume-Uni] ; B. Kendall [Royaume-Uni] ; D. Kingsley [Royaume-Uni] ; S. E. Daniel [Royaume-Uni] ; N. P. Quinn [Royaume-Uni]Source :
- Movement Disorders [ 0885-3185 ] ; 1994.
English descriptors
- KwdEn :
- Adult, Aged, Atrophy, Autonomic Nervous System Diseases (radiography), Cerebellum (pathology), Computed tomography scan, Corpus Striatum (pathology), Diagnosis, Differential, Female, Follow-Up Studies, Humans, Male, Middle Aged, Multiple system atrophy, Observer Variation, Olivopontocerebellar Atrophies (radiography), Olivopontocerebellar atrophy, Parkinson Disease (radiography), Pons (pathology), Striatonigral degeneration, Substantia Nigra (pathology), Tomography, X-Ray Computed (statistics & numerical data).
- MESH :
- pathology : Cerebellum, Corpus Striatum, Pons, Substantia Nigra.
- radiography : Autonomic Nervous System Diseases, Olivopontocerebellar Atrophies, Parkinson Disease.
- statistics & numerical data : Tomography, X-Ray Computed.
- Adult, Aged, Atrophy, Diagnosis, Differential, Female, Follow-Up Studies, Humans, Male, Middle Aged, Observer Variation.
Abstract
Cranial computer tomographic (CT) images of 33 patients with multiple system atrophy (MSA) and of 40 age‐matched controls were blindly analyzed by two neuroradiologists. All patients had autonomic dysfunction, all but one had parkinsonism, and 13 had cerebellar signs. The scans were judged entirely normal in 21%. Moderate or severe infratentorial atrophy was found in 42%. Cerebellar atrophy was present in 39%, and pontine atrophy was present in 18%. Of the 13 patients with cerebellar signs, only eight had cerebellar atrophy. Of the 20 patients without cerebellar signs, five had cerebellar atrophy. Supratentorial involvement was much less common and less severe. Thus, CT demonstrated system involvement that was not evident clinically in five of 33 cases (15%). However, in all five the clinical diagnosis was already evident from the presence of both autonomic and pyramidal signs in addition to parkinsonism. We conclude that CT imaging is of limited diagnostic use in individual patients with MSA.
Url:
DOI: 10.1002/mds.870090311
Affiliations:
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J Ger</name><affiliation wicri:level="2"><country>Royaume-Uni</country><placeName><region type="country">Angleterre</region></placeName><wicri:cityArea>University Department of Clinical Neurology and Parkinson's Disease Society Brain Bank, Institute of Neurology, London</wicri:cityArea></affiliation></author><author><name sortKey="Kendall, B" sort="Kendall, B" uniqKey="Kendall B" first="B." last="Kendall">B. Kendall</name><affiliation wicri:level="2"><country>Royaume-Uni</country><placeName><region type="country">Angleterre</region></placeName><wicri:cityArea>National Hospital for Neurology and Neurosurgery, London</wicri:cityArea></affiliation></author><author><name sortKey="Kingsley, D" sort="Kingsley, D" uniqKey="Kingsley D" first="D." last="Kingsley">D. Kingsley</name><affiliation wicri:level="2"><country>Royaume-Uni</country><placeName><region type="country">Angleterre</region></placeName><wicri:cityArea>National Hospital for Neurology and Neurosurgery, London</wicri:cityArea></affiliation></author><author><name sortKey="Daniel, S E" sort="Daniel, S E" uniqKey="Daniel S" first="S. E." last="Daniel">S. E. Daniel</name><affiliation wicri:level="2"><country>Royaume-Uni</country><placeName><region type="country">Angleterre</region></placeName><wicri:cityArea>University Department of Clinical Neurology and Parkinson's Disease Society Brain Bank, Institute of Neurology, London</wicri:cityArea></affiliation></author><author><name sortKey="Quinn, N P" sort="Quinn, N P" uniqKey="Quinn N" first="N. P." last="Quinn">N. P. Quinn</name><affiliation wicri:level="2"><country>Royaume-Uni</country><placeName><region type="country">Angleterre</region></placeName><wicri:cityArea>University Department of Clinical Neurology and Parkinson's Disease Society Brain Bank, Institute of Neurology, London</wicri:cityArea></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="sub">Official Journal of the Movement Disorder Society</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="1994">1994</date><biblScope unit="vol">9</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="333">333</biblScope><biblScope unit="page" to="336">336</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">2774F505D6800EF02D9B9B5EED37CBE267815C9D</idno><idno type="DOI">10.1002/mds.870090311</idno><idno type="ArticleID">MDS870090311</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Atrophy</term><term>Autonomic Nervous System Diseases (radiography)</term><term>Cerebellum (pathology)</term><term>Computed tomography scan</term><term>Corpus Striatum (pathology)</term><term>Diagnosis, Differential</term><term>Female</term><term>Follow-Up Studies</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Multiple system atrophy</term><term>Observer Variation</term><term>Olivopontocerebellar Atrophies (radiography)</term><term>Olivopontocerebellar atrophy</term><term>Parkinson Disease (radiography)</term><term>Pons (pathology)</term><term>Striatonigral degeneration</term><term>Substantia Nigra (pathology)</term><term>Tomography, X-Ray Computed (statistics & numerical data)</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Cerebellum</term><term>Corpus Striatum</term><term>Pons</term><term>Substantia Nigra</term></keywords><keywords scheme="MESH" qualifier="radiography" xml:lang="en"><term>Autonomic Nervous System Diseases</term><term>Olivopontocerebellar Atrophies</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="statistics & numerical data" xml:lang="en"><term>Tomography, X-Ray Computed</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Atrophy</term><term>Diagnosis, Differential</term><term>Female</term><term>Follow-Up Studies</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Observer Variation</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Cranial computer tomographic (CT) images of 33 patients with multiple system atrophy (MSA) and of 40 age‐matched controls were blindly analyzed by two neuroradiologists. All patients had autonomic dysfunction, all but one had parkinsonism, and 13 had cerebellar signs. The scans were judged entirely normal in 21%. Moderate or severe infratentorial atrophy was found in 42%. Cerebellar atrophy was present in 39%, and pontine atrophy was present in 18%. Of the 13 patients with cerebellar signs, only eight had cerebellar atrophy. Of the 20 patients without cerebellar signs, five had cerebellar atrophy. Supratentorial involvement was much less common and less severe. Thus, CT demonstrated system involvement that was not evident clinically in five of 33 cases (15%). However, in all five the clinical diagnosis was already evident from the presence of both autonomic and pyramidal signs in addition to parkinsonism. We conclude that CT imaging is of limited diagnostic use in individual patients with MSA.</div></front></TEI><affiliations><list><country><li>Royaume-Uni</li></country><region><li>Angleterre</li></region></list><tree><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Wenning" sort="Wenning" uniqKey="Wenning" last="Wenning">Wenning</name></region><name sortKey="Daniel, S E" sort="Daniel, S E" uniqKey="Daniel S" first="S. E." last="Daniel">S. E. Daniel</name><name sortKey="J Ger, R" sort="J Ger, R" uniqKey="J Ger R" first="R." last="J Ger">R. J Ger</name><name sortKey="Kendall, B" sort="Kendall, B" uniqKey="Kendall B" first="B." last="Kendall">B. Kendall</name><name sortKey="Kingsley, D" sort="Kingsley, D" uniqKey="Kingsley D" first="D." last="Kingsley">D. Kingsley</name><name sortKey="Quinn, N P" sort="Quinn, N P" uniqKey="Quinn N" first="N. P." last="Quinn">N. P. Quinn</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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